ABOUT US

We are an interdisciplinary research group focusing on droplets and soft granular matter physics, and tissue engineering. We use droplet microfluidics to formulate and study droplet-based materials as well as to engineer biomaterials at the microscale for new applications in 3D cell culture and tissue engineering.

Soft granular materials are structures composed of close-packed deformable particles, droplets, or other types of ‘grains’. Examples include compressed emulsions, foams,  or dense micro-hydrogel suspensions, widespread in food, cosmetic, and pharmaceutical industries.  We focus on developing new strategies of formulation of such ‘wet’ granular materials with high precision using microfluidics. We use viscous flows to generate and manipulate droplets inside microchannels and build larger granular structures exploiting capillary and viscous forces. We study mechanical properties and self-assembly of droplet aggregates, clusters, or threads. We also exploit microfluidics and 3D printing to engineer biomaterials, e.g., fabricate porous hydrogel scaffolds for cell seeding or formulate cell-laden hydrogel microstructures as microparticles/microfibers as building blocks of larger tissue-like constructs.  The great promise of the living tissue-like microstructures is their application in:

  • the modeling of healthy tissues for a better understanding of tissue morphology and physiology (e.g., vasculature) or drug cytotoxicity studies,
  • the modeling of diseased tissues (e.g., tumors) for drug efficacy testing, or
  • regenerative medicine, which is the fabrication of implantable tissues or tissue parts (pancreatic islets, muscle tissue).

Publications

2020

  • Kao, Y. T.;  Kaminski, T. S.;  Postek, W.;  Guzowski, J.;  Makuch, K.;  Ruszczak, A.;  von Stetten, F.;  Zengerle, R.; Garstecki, P., Gravity-driven microfluidic assay for digital enumeration of bacteria and for antibiotic susceptibility testing. Lab on a Chip 2020, 20 (1), 54-63.
  • Pierini, F.Guglielmelli, A.Urbanek, O.Nakielski, P.Pezzi, L.Buda, R.Lanzi, M.Kowalewski, T. A.De, L.Thermoplasmonic‐Activated Hydrogel Based Dynamic Light AttenuatorAdv. Optical Mater. 20208, 2000324.

2019

  • Costantini, M.; Jaroszewicz, J.;  Kozon, L.;  Szlazak, K.;  Swieszkowski, W.;  Garstecki, P.;  Stubenrauch, C.;  Barbetta, A.; Guzowski, J., 3D-Printing of Functionally Graded Porous Materials Using On-Demand Reconfigurable Microfluidics. Angewandte Chemie-International Edition 2019, 58 (23), 7620-7625.
  • Guzowski, J.; Gim, B., Particle clusters at fluid-fluid interfaces: equilibrium profiles, structural mechanics and stability against detachment. Soft Matter 2019, 15 (24), 4921-4938.
  • Rinoldi, C.; Costantini, M.;  Kijenska-Gawronska, E.;  Testa, S.;  Fornetti, E.;  Heljak, M.;  Cwiklinska, M.;  Buda, R.;  Baldi, J.;  Cannata, S.;  Guzowski, J.;  Gargioli, C.;  Khademhosseini, A.; Swieszkowski, W., Tendon Tissue Engineering: Effects of Mechanical and Biochemical Stimulation on Stem Cell Alignment on Cell-Laden Hydrogel Yarns. Advanced Healthcare Materials 2019, 8 (7).
    • https://doi.org/10.1002/adhm.201801218

2018

  • Costantini, M.; Guzowski, J.;  Zuk, P. J.;  Mozetic, P.;  De Panfilis, S.;  Jaroszewicz, J.;  Heljak, M.;  Massimi, M.;  Pierron, M.;  Trombetta, M.;  Dentini, M.;  Swieszkowski, W.;  Rainer, A.;  Garstecki, P.; Barbetta, A., Electric Field Assisted Microfluidic Platform for Generation of Tailorable Porous Microbeads as Cell Carriers for Tissue Engineering. Advanced Functional Materials 2018, 28 (20).
  • Mezhericher, M.; Nunes, J. K.;  Guzowski, J. J.; Stone, H. A., Aerosol-assisted synthesis of submicron particles at room temperature using ultra-fine liquid atomization. Chemical Engineering Journal 2018, 346, 606-620.

2016

  • Guzowski, J.;  Gizynski, K.;  Gorecki, J.; Garstecki, P., Microfluidic platform for reproducible self-assembly of chemically communicating droplet networks with predesigned number and type of the communicating compartments. Lab on a Chip 2016, 16 (4), 764-772.

2015

  • Gorecki, J.; Gizynski, K.;  Guzowski, J.;  Gorecka, J. N.;  Garstecki, P.;  Gruenert, G.; Dittrich, P., Chemical computing with reaction-diffusion processes. Philosophical Transactions of the Royal Society a-Mathematical Physical and Engineering Sciences 2015, 373 (2046), 20140219.
    • https://doi.org/10.1098/rsta.2014.0219
  • Guzowski, J.; Garstecki, P., Droplet Clusters: Exploring the Phase Space of Soft Mesoscale Atoms. Physical Review Letters 2015, 114 (18), 188302.

2014

  • Costantini, M.; Colosi, C.;  Guzowski, J.;  Barbetta, A.;  Jaroszewicz, J.;  Swieszkowski, W.;  Dentini, M.; Garstecki, P., Highly ordered and tunable polyHIPEs by using microfluidics. Journal of Physical Chemistry B 2014, 2, 2290-2300.
  • Guzowski, J.; Garstecki, P., Comment on “Wetting-induced formation of controllable monodisperse multiple emulsions in microfluidics” by N.-N. Deng, W. Wang, X.-J. Ju, R. Xie, D. A. Weitz and L.-Y. Chu, Lab Chip, 2013, 13, 4047. Lab on a Chip 2014, 14 (8), 1477-1478.

2013

  • Guzowski, J.;  Jakiela, S.;  Korczyk, P. M.; Garstecki, P., Custom tailoring multiple droplets one-by-one. Lab on a Chip 2013, 13 (22), 4308-4311.

2012

  • Guzowski, J.;  Korczyk, P. M.;  Jakiela, S.; Garstecki, P., The structure and stability of multiple micro-droplets. Soft Matter 2012, 8 (27), 7269-7278.

2011

  • Guzowski, J.; Tasinkevych, M.; Dietrich, S., Effective interactions and equilibrium configurations of colloidal particles on a sessile droplet. Soft Matter 2011, 7 (9), 4189-4197.
  • Guzowski, J.; Tasinkevych, M.; Dietrich, S., Capillary interactions in Pickering emulsions. Physical Review E 2011, 84 (3), 031401.
  • Guzowski, J.; Korczyk, P. M.;  Jakiela, S.; Garstecki, P., Automated high-throughput generation of droplets. Lab on a Chip 2011, 11 (21), 3593-3595.

2010

  • Guzowski, J.;  Tasinkevych, M.; Dietrich, S., Free energy of colloidal particles at the surface of sessile drops. European Physical Journal E 2010, 33 (3), 219-242.

2008

  • Guzowski, J.;  Cichocki, B.;  Wajnryb, E.; Abade, G. C., The short-time self-diffusion coefficient of a sphere in a suspension of rigid rods. Journal of Chemical Physics 2008, 128 (9).

Job offers

Contact

  • Instytut Chemii Fizycznej Polskiej Akademii Nauk
    ul. Kapsrzaka 44/52, Warszawa
  • +48 22 3433406
  • jguzowski@ichf.edu.pl
  • https://sgmte.pl/
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